Journal: Frontiers in Oncology
Article Title: Machine learning-featured Secretogranin V is a circulating diagnostic biomarker for pancreatic adenocarcinomas associated with adipopenia
doi: 10.3389/fonc.2022.942774
Figure Lengend Snippet: Unbiased transcriptomic analysis shows that pancreatic SCG5 expression is associated with the adipopenia phenotype. (A) Bubble plot summarizing the results of gene set enrichment analysis (GSEA) dissecting adipose transcriptomic profiles from donors of pancreatic SCG5 -high or -low groups. (B) Representative enrichment plots of cachexia and adipopenia-related gene sets. (C–F) Gene networks comparing correlations among top genes of each indicated gene set, human phenotype ontology (HP) Lipodystrophy (C) , HP Cachexia (D) , Gene Ontology biological process (GOBP) Mitochondrial respiratory chain complex assembly (E) , and GOBP Brown fat cell differentiation (F) .
Article Snippet: The GSEA Java desktop program (GSEA v. 4.1.0 for Windows) was downloaded from the website of Broad Institute ( https://www.gsea-msigdb.org ).
Techniques: Expressing, Cell Differentiation